KANSAS CITY, Mo. (AP) — The Chiefs’ Patrick Mahomes is just as efficient at home as he is on the road. He gets the same results, too. After winning his first three starts, all away from Arrowhead Stadium, the second-year pro finally made his regular-season home debut Sunday. Mahomes responded by torching San Francisco’s banged-up pass defense for 314 yards and three touchdowns in a 38-27 victory over the 49ers.

Mahomes now has 13 touchdown passes without an interception, breaking the NFL record for TD passes in the first three weeks of a season. Peyton Manning threw 12 to start the 2013 campaign. Mahomes’ touchdown passes to Chris Conley, Demetrius Harris and Sammy Watkins , along with a pair of TD runs by Kareem Hunt, helped Kansas City (3-0) race to a 35-7 lead late in the first half.

Few leads are safe against the Chiefs’ porous defense, though. The 49ers (1-2) rallied behind running backs Matt Breida and Alfred Morris, who kept gouging the Chiefs’ defensive front, and Jimmy Garoppolo, who threw for 251 yards and two scores . It was Garoppolo’s 11-yard pass to Marquis Goodwin early in the third quarter that started the comeback, and Morris scored on a short touchdown run later in the quarter to make it 35-24.

After the Chiefs tacked on a field goal early in the fourth to extend their lead, the 49ers came back with a grinding, 17-play drive that wiped out more than half the period. But it ended in a strange sequence that began with Garoppolo taking a hard hit from Steven Nelson along the sideline. Garoppolo easily could have stepped out of bounds, but instead he was crushed on his throwing shoulder and had to leave.

C.J. Beathard came in and threw what appeared to be a fourth-down touchdown pass to George Kittle, but it was wiped out by offensive pass interference. There was only 5:17 left, but rather than go for it on fourth-and-goal at the Kansas City 25, 49ers coach Kyle Shanahan elected to kick a field goal — keeping it a two-possession game.
San Francisco proceeded to kick it deep rather than try an onside kick. The Chiefs picked up a first down on a penalty, and Hunt churned his way for two more first downs to put the game away.

The 49ers have not won in Arrowhead Stadium since Dec. 26, 1982.
UP NEXT…49ers: Play the Chargers in Los Angeles next Sunday. Chiefs: Visit the AFC West-rival Broncos next Monday night.

(2-1) AHSTW, Avoca 21-14-15, Atlantic 13-21-10
(2-0) AHSTW, Avoca 21-21, CAM, Anita 15-13
(2-0) AHSTW, Avoca 21-21, Southwest Valley 11-17
(2-1) AHSTW, Avoca 27-23-15, Panorama 25-25-13
(2-1) Atlantic 21-13-17, CAM, Anita 18-21-15
(2-0) Audubon 21-21, Exira-EHK 15-14
(2-1) Bishop Heelan 21-10-15, Council Bluffs, Abraham Lincoln 16-21-12
(2-0) Bishop Heelan 22-21, Sioux City, North 20-16
(2-1) Council Bluffs, Abraham Lincoln 13-21-15, Lewis Central 21-11-11
(2-0) Council Bluffs, Abraham Lincoln 21-21, Hinton 17-7
(2-0) Council Bluffs, Abraham Lincoln 21-21, Sheldon 12-15
(2-0) Council Bluffs, Abraham Lincoln 21-21, Sioux City, East 8-15
(2-0) Council Bluffs, Abraham Lincoln 21-21, Sioux City, North 10-15
(2-1) Council Bluffs, Thomas Jefferson 21-9-15, Fremont-Mills 16-21-6
(2-0) Dallas Center-Grimes 21-21, Carroll 11-17
(2-1) East Mills 19-21-15, Central Decatur, Leon 21-9-9
(2-1) East Union 11-21-15, Central Decatur, Leon 21-11-12
(2-1) Griswold 21-8-15, Fremont-Mills 17-21-3
(2-1) Kuemper Catholic, Carroll 12-21-16, Sergeant Bluff-Luton 21-16-14
(2-0) Kuemper Catholic, Carroll 21-21, LeMars 9-14
(2-0) Kuemper Catholic, Carroll 21-21, Sioux Center 11-8
(2-0) Kuemper Catholic, Carroll 21-21, Southwest Christian 14-12
(2-1) Kuemper Catholic, Carroll 23-19-15, Unity Christian 21-21-12
(2-0) Kuemper Catholic, Carroll 24-21, Sioux Falls Christian 22-10
(2-0) Lenox 21-21, Audubon 12-18
(2-0) Lenox 21-21, Exira-EHK 13-11
(2-0) Mount Ayr 25-25, Central Decatur, Leon 13-19
(2-1) Panorama 14-21-15, AHSTW, Avoca 21-14-13
(2-1) Panorama 21-18-15, Lenox 16-21-4
(2-0) Panorama 21-21, Atlantic 18-12
(2-0) Panorama 21-21, CAM, Anita 17-19
(2-0) Sergeant Bluff-Luton 21-21, LeMars 17-8
(2-0) Sidney 21-21, Council Bluffs, Thomas Jefferson 12-9
(2-0) Sidney 21-21, East Atchison 4-8
(2-0) Sidney 21-21, Fremont-Mills 6-8
(2-0) Sidney 21-21, Griswold 11-9
(2-1) Southwest Valley 17-24-15, Audubon 21-22-5
(2-0) Southwest Valley 21-21, Lenox 16-16
(2-1) Southwest Valley 23-15-15, Lenox 21-21-6
(2-0) Unity Christian 21-21, LeMars 9-10
(2-1) West Monona 21-14-15, Westwood, Sloan 10-21-7
(2-0) West Monona 21-21, Lawton-Bronson 13-12
(2-0) West Monona 21-21, River Valley 15-6
(2-1) Woodbury Central 21-14-15, West Monona 16-21-13

CEDAR FALLS, Iowa (AP) — Eli Dunne threw three touchdown passes, Trevor Allen and Marcus Weymiller each ran for a score and Northern Iowa forced five turnovers in shutting out Hampton 44-0 on Saturday. Dunne was 16 of 23 for 191 yards passing, with TD strikes of 19 yards to Nick Fossey and 12 yards to Deion McShane. Delmon Williams was 4 of 16 for 52 yards passing for Hampton (1-2), with three interceptions.

Here is the latest Mid-America sports news from The Associated Press

IOWA CITY, Iowa (AP) — Alex Hornibrook threw a 17-yard TD pass to A.J. Taylor with 57 seconds left and No. 18 Wisconsin bounced back from last week’s loss by rallying past Iowa 28-17. Jonathan Taylor had 113 yards rushing and Alec Ingold ran for a 33-yard score with 22 seconds left for the Badgers, who also got a major leg up the Hawkeyes _ perhaps their biggest threat in the Big Ten West race _ in their league opener.

AMES, Iowa (AP) — Zeb Noland threw for 233 yards and a TD, David Montgomery had 107 yards rushing and a score and Iowa State held off Akron 26-13 for its first win of the season. Connor Assalley added four field goals for the Cyclones (1-2), who put forth an underwhelming performance ahead of a brutal stretch in the Big 12.

ANN ARBOR, Mich. (AP) — Karan Higdon ran for 136 yards and a touchdown in the first half to help No. 19 Michigan build a huge lead and it coasted 56-10 over Nebraska. The Wolverines led 20-0 after the first quarter and 39-0 at halftime. The Cornhuskers are off to their worst start since 1945; they have lost seven in a row for the first time since 1957. Michigan rested Higdon in the second half after he missed the previous game with an injury.

ST. LOUIS (AP) — Tyler O’Neill hit a solo home run with two outs in the 10th inning and the St. Louis Cardinals held their playoff position, rallying past the San Francisco Giants 5-4. Yadier Molina also homered for St. Louis, which began the day 1 ½ games ahead of Colorado for the second NL wild-card spot. The Cardinals, who have seven games remaining, started three games behind Milwaukee for the top wild-card slot. St. Louis won for the fifth time in six games. San Francisco has lost three in a row.

DETROIT (AP) — Mikie Mahtook hit a two-run homer in the eighth inning, and the Detroit Tigers beat the Kansas City Royals 5-4 in Victor Martinez’s final major league game. With the score tied at 3, Niko Goodrum led off the eighth with his third hit of the game, a single off Jason Hammel. Mahtook then lined Hammel’s 1-0 slider over the left-field fence for his ninth homer. Martinez had an infield single in his first at-bat and was lifted for a pinch-runner.