Here is the latest Iowa news from The Associated Press at 3:40 a.m. CDT

DES MOINES, Iowa (AP) — Top Democratic presidential candidates clashed over health care as they sought to stand out from the pack in Iowa at a raucous event kicking off the three-month sprint to the first-in-the-nation caucuses. Joe Biden opened the state Democratic Party’s marquee annual fundraiser Friday by swiping at the candidate who has largely caught him atop the Democratic primary polls, Elizabeth Warren. Meanwhile, Pete Buttigieg sought to take up the mantle of another young, upstart candidate, Barack Obama.

DES MOINES, Iowa (AP) — The Iowa Board of Corrections announced Friday that Jerry Larson will be the new warden at Anamosa State Penitentiary. The board unanimously voted Friday to appoint Larson to replace William Sperfslage, who was earlier this year named the state’s new deputy director of institutions. Larson has been the deputy warden at Newton Correctional Facility since 2016 and started his career at the Fort Dodge Correctional Facility. He was a correctional officer there in 1999.

VINING, Iowa (AP) — Iowa environmental officials are investigating a manure spill that led to a fish kill in east-central Iowa. The Iowa Department of Natural Resources said in a news release Friday that the fish kill was found on Wolf Creek about 2 miles northwest of Vining. Department staff say a manure applicator for Mayo Farm Inc. reported Thursday morning that a drag hose leaked about 2,600 gallons of manure during land application.

ANKENY, Iowa (AP) — A state board has approved post-traumatic stress disorder and intellectual disability with aggression to the number of medical conditions that can legally be treated by medical marijuana in Iowa but rejected two other conditions petitioners had requested. The Iowa Medical Cannabidiol Board voted Friday to not allow patients with opioid dependency and those with Alzheimer’s Disease to have legal access to medical marijuana.