Here is the latest Mid-America sports news from The Associated Press

AMES, Iowa (AP) — Freshman Spencer Sanders threw for 249 yards and two TDs and Oklahoma State upset 23rd-ranked Iowa State 34-27, snapping the Cyclones’ three-game winning streak. Chuba Hubbard had 116 yards rushing for the Cowboys, who used four big plays to snap their two-game skid. Malcolm Rodriguez gave Oklahoma State a 34-27 lead with 6:47 to go on an interception he returned 26 yards for a touchdown.

EVANSTON, Ill. (AP) — Nate Stanley passed for 179 yards and a touchdown and Iowa allowed just 202 yards as the 20th-ranked Hawkeyes routed Northwestern 20-0. Mekhi Sargent had a rushing touchdown and Tyler Goodson added 58 yards rushing on 11 carries as Iowa earned its second shutout of the season. Aidan Smith completed 18 of 32 passes for 138 yards with an interception as Northwestern dropped its fifth straight.

LINCOLN, Neb. (AP) — Peyton Ramsey passed for a career-high 351 yards and two touchdowns, Whop Philyor caught 14 balls for 178 yards, and Indiana became bowl eligible with a 38-31 win over Nebraska. The Hoosiers won a third straight conference game in the same season for the first time since 1993 and won in Lincoln for the first time since 1959.

LINCOLN, Neb. (AP) — Nebraska backup Noah Vedral was injured in the second quarter against Indiana and third-string quarterback Luke McCaffrey has replaced him. Vedral drew the start in place of Adrian Martinez, who injured his left leg in the Oct. 5 game against Northwestern and missed the Cornhuskers’ Oct. 12 game at Minnesota.

MANHATTAN, Kan. (AP) — Kansas State dealt a big blow to No. 5 Oklahoma’s national title hopes, holding on for a 48-41 victory Saturday. Skylar Thompson threw for 213 yards while running for four scores, and the Wildcats’ defense did just enough against Jalen Hurts and the Sooners’ prolific offense. When a video review overturned a final onside kick with 1:45 left, the Wildcats had their first home win over Oklahoma since 1996.

LEXINGTON, Ky. (AP) — Lynn Bowden Jr. rushed for 204 yards and two touchdowns to lead Kentucky to a 29-7 win over Missouri. The two teams combined for seven fumbles and four lost miscues in a steady rain that didn’t seem to bother Bowden, who was nearly unstoppable. Sparked by Bowden, the Wildcats rushed for 297 yards.

LAWRENCE, Kan. (AP) — Douglas Coleman fumbled on a blocked field goal return with two seconds to go and Liam Jones capitalized with a 32-yard field goal to give Kansas a 37-34 win over Texas Tech. Nick McCann blocked Jones’ 40-yard attempt and the ball landed in the hands of Coleman, who ran to his left before attempting a lateral that did not touch another Tech player.