ST. LOUIS (AP) – Welington Castillo hit a three-run homer in the 11th inning off closer Trevor Rosenthal, who struck out with an unusual chance to win it, and the Chicago Cubs beat the St. Louis Cardinals 6-3 on Friday night.

The Cardinals had runners on first and second with two outs in the 10th when manager Mike Matheny decided against a pinch hitter. Rosenthal (0-1) took a called third strike in his second career at-bat.

Nate Schierholtz doubled for his fourth straight hit leading off the 11th and advanced on a sacrifice. Starlin Castro was intentionally walked and Ryan Kalish popped out on a bunt attempt before Castillo lined a 1-1 fastball 426 feet to left for his second homer.

Justin Grimm (1-0) walked Matt Holliday and Matt Adams on eight pitches to start the 10th but got out of it, partly because Matheny left Pete Kozma and Tony Cruz on the bench. Hector Rondon finished for his first career save.