JUPITER, Fla. (AP) — Johan Santana cleared another hurdle in his comeback from shoulder surgery. The New York Mets left-hander pitched six innings in his longest outing of spring training in a 2-1 loss to the St. Louis Cardinals on Wednesday. Santana allowed a run on six hits in six innings with six strikeouts. Santana worked six innings for the first time since Aug. 28, 2010 against the Astros. The lone run came on an RBI single by Lance Berkman in the sixth. Mets Manager Terry Collins is optimistic about Santana return to major league action. He’s lined up to start the April 5 opener at home against the Braves. Cardinals starter Jake Westbrook was even stingier, working six scoreless innings while allowing three hits. Westbrook has allowed one earned run in 15 innings. Westbrook is the first St. Louis pitcher to go six innings. The Mets are a major-league worst 4-12 this spring, while the Cardinals are 10-4.